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lumacaftor/ivacaftor will reduce the level or effect of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of abemaciclib with solid CYP3A4 inducers lessens plasma focus of abemaciclib and its metabolites.Abemaciclib targets CDK4 and CDK6, proteins that support regulate cell